RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas

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Copy number alteration signature defines undifferentiated pleomorphic sarcomas and leiomyosarcomas with poor prognosis

Results LMS presented lower frequency of genomic alterations in comparison with UPS. None of the variables were identified as independent prognostic factors, but gains at 1q21.3 were significantly associated with poor survival and showed almost significance as an independent prognostic factor (relative risk 13.8, P = 0.019). In addition, copy number profile of UPS and LMS was indistinguishable ...

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Genomic Signatures Predict Poor Outcome in Undifferentiated Pleomorphic Sarcomas and Leiomyosarcomas

Undifferentiated high-grade pleomorphic sarcomas (UPSs) display aggressive clinical behavior and frequently develop local recurrence and distant metastasis. Because these sarcomas often share similar morphological patterns with other tumors, particularly leiomyosarcomas (LMSs), classification by exclusion is frequently used. In this study, array-based comparative genomic hybridization (array CG...

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Undifferentiated pleomorphic sarcoma*

Dear Editor, By definition, sarcomas are malignant tumors of tissues, derived from mesoderm and involve the oncogenic transformation of mesenchymal stem cells. The two main types of sarcoma are bone and soft tissue sarcomas. Soft tissue sarcomas generally manifest as deep lesions, but they may affect the skin and subcutaneous tissue.1 They are grouped according to similarities in their clinical...

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Undifferentiated Pleomorphic Sarcoma in Mandible

Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma, occurs commonly in the soft tissues in adult, but is rare in the maxillofacial region. It consists of undifferentiated mesenchymal tumor cells resembling histiocytes and fibroblasts. The purpose of this article is to report a case of UPS in the mandible. A 44-year-old patient presented with a painful...

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Gene Expression Profiling in Leiomyosarcomas and Undifferentiated Pleomorphic Sarcomas: SRC as a New Diagnostic Marker

BACKGROUND Undifferentiated Pleomorphic Sarcoma (UPS) and high-grade Leiomyosarcoma (LMS) are soft tissue tumors with an aggressive clinical behavior, frequently developing local recurrence and distant metastases. Despite several gene expression studies involving soft tissue sarcomas, the potential to identify molecular markers has been limited, mostly due to small sample size, in-group heterog...

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ژورنال

عنوان ژورنال: Cancer

سال: 2015

ISSN: 0008-543X

DOI: 10.1002/cncr.29733